Republicans are now virtually assured of keeping control of the Senate in the midterm elections.
The race for the Texas Senate seat has been one of the most widely publicised and fiercely competitive of the midterm election run-up.
The incumbent Mr Cruz, faced an unexpected challenge in the charismatic media favourite, challenger Beto O’Rourke.
However, the deeply conservative Republican led consistently in the polls and the outcome did not come as a surprise.
Texas is a Republican stronghold, with the party holding the governor’s mansion, both Senate seats, and safe majorities in both chambers.
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Democrats haven’t won statewide since 1994.
Mr Cruz’s victory came along a series of other GOP’s victories, which dashed any hopes of a Democratic takeover in the Senate.
Democratic Heidi Heitkamp and Joe Donnelly, were ousted in North Dakota and Indiana, respectively.
In Florida, Republican Governor Rick Scott won against Democratic Sen. Bill Nelson.
In Missouri, Republican Josh Hawley clung a significant lead over Democratic Sen. Claire McCaskill.
However, the Democrats remain on course to take the House of Representatives.
They need to pick up 23 seats to gain control of the House of Representatives from the Republican Party and exit polls have predicted a blue wave in these midterms.
But it appears the “wave” has failed to reach the upper chamber.
The White House Press Secretary Sarah Sanders told reporters in the White House driveway: “Anybody that was anticipating a blue wave tonight is not going to get it.
“Maybe you get a ripple but I certainly don’t think there’s a blue wave.”