In what is arguably the biggest game of the season to date, two teams with a 9-1 record go head to head in Los Angeles.
The match was set to be played in Mexico, however a poor pitch had the huge game moved back to California.
The Rams’ only defeat came to the New Orleans Saints in a thrilling encounter, being on the wrong end of a 45-35 scoreline.
For the Chiefs, their only loss came at the hands of Tom Brady and the New England Patriots back in NFL Week 6.
Tonight’s clash will see Chiefs’ Patrick Mahomes come up against Jared Goff of the Rams at quarterback.
And Chiefs coach Andy Reid admitted that the two could well be promising players going forward, but stated it is too early to call the game a rivalry.
“Listen, I’m terrible at predicting the future, but it would look that way, right?” he said.
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“For the NFL, I just think those are not only two good players, but good guys.
“They’re good for their teams, they’re good for the league, they’re good for kids that watch them, all those things that are important about our game.
“I think both of them have a real chance to leave a mark on it.”
How to watch Chiefs vs Rams LIVE on TV
The final game of NFL Week 11 is live on Sky Sports with the match scheduled to begin at 1.20am.
Sky Sports Main Event, available on Sky channel 401, will show the game live with the match also on Sky Sports Action.
How to watch Chiefs vs Rams LIVE online
Sky subscribers can live stream Kansas City Chiefs vs Los Angeles Rams online via SkyGo and the SkyGo app.
The match can be followed live on your desktop or laptop via the Sky Go app, which if you’re an existing customer, is also available on iOS and Android smartphone and tablet devices.
Sky Go is also available on a number of platforms including Amazon Fire devices, iPad, Mac computers and laptops, Playstation 3, PS4 and Xbox One.
The Sky Sports app, available to download on iOS and Android devices, will also be providing live text coverage and updates.
If you’re not currently a Sky Sports customer but can’t stand to miss out on the action, you can add the channels to your box via a NOW TV subscription.
Day passes, which let you add Sky Sports channels for 24 hours, start at £7.99 a day, with a weekly pass starting from £12.99, and no locking in to a contract.
NOW TV doesn’t even require a typical television to use, as it is also available on a NOW TV Box, Chromecast, PS4, PS3, Xbox One, Xbox 360, Roku, LG Smart TV, PC or Mac, and selected mobile and tablet devices.