The young astronomy enthusiasts from Highland Village, Texas, will have a 20-minute window today to send their most burning questions out into space.
At exactly 1.10pm EST (6.10pm GMT) the group will reach out to Expedition 54 astronaut Joe Acaba, to ask about life onboard the ISS.
Thanks to NASA, the entire Earth-to-space call will stream live online on NASA TV and the space agency’s NASA LIVE website.
You can also watch the conference call in the embedded NASA YouTube live feed above.
The downlink call will take place at Briarhill Middle School, where a thousand students are expected to grill Mr Acaba about his life and deep-space research in zero-gravity.
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The American space agency teased: “Students have been preparing for this downlink by studying the solar system, universe, gravitational effects on plants and animals, plotting space station coordinates, calculating distances to various planets, planning what to pack for a journey to Mars using surface and volume formulas, and using ratios/proportions to paint a life size version of the International Space Station on their football field.
“About 1,000 students and teachers are expected to be at Briarhill for the downlink.”
NASA added: “Linking students directly to astronauts aboard the space station provides unique, authentic experiences designed to enhance student learning, performance and interest in science, technology, engineering and mathematics (STEM).
“This in-flight education downlink is an integral component of NASA’s Year of Education on Station, which provides extensive space station-related resources and opportunities to students and educators.”
Mr Acaba, who arrived on the ISS on September 12 for his this third mission to space, will return to Earth next month.
He has been a NASA astronaut candidate since 2004 and has logged more than 130 days in space on his first two missions alone.
Onboard the impressive ISS, the astronaut and hydrogeologist was responsible for lubricating one of the space station’s robotic arms in October last year.
The ISS constantly circles above the planet at breakneck speeds, some 240 miles above ground.
The space station orbits Earth roughly every 90 minutes, completing up to 15 full trips in a day.
Astronauts from all over the globe stationed at the ISS carry out crucial scientific research about life in space.
Watch more: NASA ISS live stream – Watch the International Space Station fly over Earth