The train was carrying Republican lawmakers and staff to a political retreat in West Virginia when it collided with the lorry in the last half hour.
The driver of the lorry is believed to be receiving medical treatment along with at least one passenger on the train.
A White House official confirmed the incident to CBS. They said they were not aware of any fatalities.
The crash took place at the corner of Lanetown Road and Marymart Farm Road around 15 miles out of Charlottesville, Virginia.
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