The Oslo Police District reported that several shots were fired at a nightclub. Police confirmed that at least two people were killed and several more seriously wounded.
A suspect is in custody but the circumstances of the shooting were unclear.
The crime scene extended from the London Pub via a neighbouring club and onwards to a nearby street where the suspect was apprehended a few minutes after the shooting began, police spokesman Tore Barstad told newspaper Aftenposten.
The London Pub is a popular gay bar and nightclub in the centre of Oslo.
The Oslo police department said in a tweet: “Two people have been confirmed dead in the shooting episode.
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“There are several seriously injured. The police defined the mission as a PLIVO incident.”
The motive of the attack is not clear yet.
Journalist Olav Roenneberg of public broadcaster NRK reported: “I saw a man arrive with a bag, he picked up a gun and started to shoot.”
Oslo is due to hold its annual Pride parade later on Saturday.
Photographs published by newspaper VG, broadcaster NRK and others show a large gathering of emergency responders outside the London Pub, including police and ambulance workers.
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He then killed 69 people, mostly teenagers, in a shooting rampage at a political summer camp.
The terrorist, Anders Behring Breivik, received a 21-year sentence for the attacks, the maximum under Norwegian law.
He was denied parole in February by a Norwegian court that said he “appeared devoid of empathy and compassion for the victims of the terror”.