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California Offers Direct Purchase of Opioid Overdose Antidote
SACRAMENTO, Calif. – In a move to enhance accessibility and reduce the financial burden of life-saving medication, California has launched a program allowing residents to directly purchase opioid reversal drugs from the state. Officials announced on Monday that individuals can now acquire naloxone, a critical medication used to counter opioid overdoses, through the state’s new initiative.
State Expands Access to Generic Naloxone
Building upon its previous efforts, California is now extending its program beyond businesses and local governments to include individual consumers. Last year, the state began offering its own cost-effective generic version of Narcan at $24 per twin-pack. This initiative makes the medication available online to individuals, representing a significant saving compared to standard pharmacy and online marketplace prices, where a similar two-dose package of naloxone nasal spray ranges from $45 to $70.
Combating Rising Overdose Rates
The urgency of this program is underscored by the alarming increase in opioid overdose fatalities in California and nationwide. Opioids, including heroin, fentanyl, and oxycodone, have contributed to a dramatic surge in deaths, reaching 7,847 in California alone in 2023. However, state authorities indicate that recent data suggests a potential decrease in these preventable deaths.
CalRx Initiative Drives Down Drug Costs
This direct-to-consumer program is a key component of California Governor Gavin Newsom’s broader strategy to challenge pharmaceutical companies to lower drug prices. The CalRx label, under which the state offers these medications, aims to provide more affordable, competitive versions of essential drugs.
Governor Newsom’s Statement on Affordable Medication
“Essential medications shouldn’t carry exorbitant costs,” stated Governor Newsom. “CalRx is designed to ensure that vital drugs like naloxone are affordable and accessible to everyone, not just a select few.”

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Naloxone Availability and Prescription Status
Since March 2023, naloxone has been available over-the-counter in the United States. This followed the U.S. Food and Drug Administration’s approval of Narcan, a nasal spray version of naloxone produced by Emergent BioSolutions, a pharmaceutical company based in Maryland. The state program further enhances this accessibility by offering a lower-cost alternative directly to consumers.
Future Plans for Affordable Insulin
California’s commitment to affordable medication extends beyond naloxone. The state is actively developing plans to make insulin more accessible and affordable for residents with diabetes. California has established an agreement with Civica, a non-profit pharmaceutical company, to manufacture CalRx-branded insulin, further demonstrating its dedication to lowering the cost of crucial medications.