David de Gea returns in goal for Manchester United, one of five changes from the team that beat Sheffield United on Thursday. Dan James, Scott McTominay, Fred and Luke Shaw replaces Mason Greenwood, Nemanja Matic, Paul Pogba and Alex Telles.
Leeds are unchanged from the team that thumped Newcastle on Wednesday.
Manchester United (4-2-3-1) de Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; James, Fernandes, Rashford; Martial.
Substitutes: Henderson, Bailly, Telles, Mata, Matic, Cavani, Pogba, van de Beek, Greenwood.
Leeds United (4-1-4-1) Meslier; Dallas, Ayling, Cooper, Alioski; Phillips; Raphinha, Rodrigo, Klich, Harrison; Bamford.
Substitutes: Casilla, Struijk, Davis, Casey, Hernandez, Shackleton, Poveda-Ocampo, Roberts, Costa.
Referee Anthony Taylor.