Centre Hadleigh Parkes and winger Josh Adams are the two players starting for Wales today who also started their last match against Fiji.
For Uruguay, German Kessler, Diego Arbelo, Manuel Leindekar, Felipe Berchesi, Nicolas Freitas and Andres Vilaseca are the men to retain their places.
Wales: Halfpenny; Adams, Watkin, Parkes, Amos; Patchell, A Davies; Smith, Elias, Lewis, B Davies, Beard, Shingler, Tipuric (capt), Wainwright.
Replacements: Dee, Carre, W Jones, Ball, Moriarty, James Davies, T Williams, G Davies.
Uruguay: Mieres; Leivas, Cat, Vilaseca, Freitas; Berchesi, Arata; Sanguinetti, Kessler, Arbelo, Dotti, Leindekar, Gaminara (capt), Civetta, Nieto.
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Replacements: Pujadas, Echeverria, Rombys, Magno, Diana, Ormaechea, Inciarte, Silva.
Referee: Angus Gardner (Australia); Assistant referees: Luke Pearce (England), Karl Dickson (England); TMO: Rowan Kitt (England).