“Big game and Marcus Mariota was intent on being out there,” NFL Network Insider Ian Rapoport said.
“But it just doesn’t seem like it’s going to happen with that stinger.”
The 25-year-old is dealing with a nerve issue, which has been affecting his right side, including his throwing shoulder, reports ESPN.
Titans are expected to turn to backup Blaine Gabbert, who has already taken several snaps this season in place of an injury-prone Mariota.
As for the Colt they are expecting tight end Eric Ebron and wide receiver TY Hilton to take to the field on Sunday.
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Both players are listed as questionable, but Ebron is expected to clear the concussion protocol.
And Hilton said Wednesday that he’d play despite dealing with an ankle injury.
Many experts favour the Colts to take the victory when they face off against the Titans on Sunday.
How to watch Tennessee Titans vs Indianapolis Colts live on TV
The NFL Week 17 game is live on Sky Sports in the UK with coverage starting at 1.10am on Monday with the game scheduled to begin at 1.20am.
Sky Sports Action on channel 408 will show the game live, while Virgin Media customers can watch the action on channel 507.
How to stream Tennessee Titans vs Indianapolis Colts live online
Sky subscribers can live stream Titans vs Colts online via SkyGo and the SkyGo app.
This means that all the match can be followed live on your desktop or laptop via the Sky Go app, which if you’re an existing customer, is also available on iOS and Android smartphone and tablet devices.
Sky Go is also available on a number of platforms including Amazon Fire devices, iPad, Mac computers and laptops, Playstation 3, PS4 and Xbox One.
The Sky Sports app, available to download on iOS and Android devices, will also be providing live text coverage and updates.
If you’re not currently a Sky Sports customer but can’t stand to miss out on the action, you can add the channels to your box via a NOW TV subscription.
Day passes, which let you add Sky Sports channels for 24 hours, start at £7.99 a day, with a weekly pass starting from £12.99, and no locking in to a contract.
NOW TV doesn’t even require a typical television to use, as it is also available on a NOW TV Box, Chromecast, PS4, PS3, Xbox One, Xbox 360, Roku, LG Smart TV, PC or Mac, and selected mobile and tablet devices.