Fury and Wilder headline a packed fight card in Los Angeles, featuring the likes of Luis Ortiz, Joe Joyce, and Robert Guerrero.
The ‘Gypsy King’ is aiming to become a two-time heavyweight champion.
He has only fought twice since defeating Wladimir Klitschko for the world titles in November 2015.
But tonight, he aims to capture the heavyweight title once again, having vacated the belts he beat Klitschko for, without ever losing in the ring.
What time are Fury and Wilder expected in the ring?
The fight is expected to start between 4.30am and 5am.
If it starts at 5am UK time, it will be at 9pm local time in Los Angeles.
The undercard has featured multiple stoppages, so it is possible the fight could be moved earlier.
The main card begins at 2am, with three fights on before Fury and Wilder are on.
Joe Joyce stopped Joe Hanks in the first round of their bout to capture the WBA inter-continental belt.
Luis Ortiz is also expected to stop Travis Kauffman in their heavyweight clash.
Jarrett Hurd and Jason Welborn go to war for the WBA, IBF, and IBO super-welterweight belts, and that is a 12-rounder.
If these fights do not go the distance, it is entirely possible that Fury and Wilder could be in the ring closer to 4.30 than 5am.