The Republic will be looking for a positive result tonight to take into Monday night’s Nations League trip to Denmark.
Northern Ireland are in the same boat as they prepare to face Austria in the same competition this weekend.
Northern Ireland manager Michael O’Neill said: “It’ll be a game that both teams will be desperate to come out and get a result in, especially with the results the way they’ve been for both teams in recent times.
“It’s an important game for both teams but there’ll be a real determination for us to go out and get a result and take something back up the road and set us up nicely for Sunday.”
Glenn Whelan will lead out the Republic of Ireland against Northern Ireland knowing his 85th cap is likely to be his last while insisting he will never retire from international football.
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The 34-year-old Aston Villa midfielder last pulled on a green shirt 12 months ago when he was used as a late substitute in Ireland’s 0-0 World Cup play-off draw in Denmark, with manager Martin O’Neill starting to turn to a new generation of players.
“Retirement, as in putting it down on paper, I’d never do that, but I know this is probably going to be the last time I play for Ireland,” Whelan said.
“But I’ve never picked when to come and play for Ireland and I’ll certainly never pick when I’m not going to play.
“The manager knows that if anything ever happens, I’ll be available.”
Republic of Ireland vs Northern Ireland – how to watch
Live coverage of the game will be shown on Sky Sports Football in the UK and Ireland.
Pre-match coverage gets underway at 7.30pm, ahead of kick-off at 7.45pm.
Existing Sky Sports customers will be able to stream the action via the Sky Go app, which can be downloaded across a host of devices.
Fans without a subscription can also live stream the match by purchasing a NOW TV sports pass.
Day Passes start at £7.99 and give you 24 hours of access to Sky Sports channels without locking into a contract.
Republic of Ireland vs Northern Ireland odds
Republic of Ireland 23/20
Draw 15/8
Northern Ireland 3/1
(Odds from Betfair)