Mr Cromwell made the comments to a Variety reporter at the fourth annual Carney Awards, which celebrate prominent actors.
He said: “If we don’t stop Trump now, then we will have a revolution for real.
“There will be blood in the streets.”
The veteran actor reiterated the warning during his acceptance speech after collecting an award.
He argued: “Something is coming up which is desperately important to this country and this planet, and that is an election, in which hopefully in some measure we are going to take back our democracy.
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“We will cut through the corruption and we won’t have to do what comes next, which is either a non-violent revolution or a violent one.”
Later Mr Cromwell was challenged on social media platform Twitter over whether he supports violent revolution.
He replied: “I do not. I believe in peaceful resistance.”
Mr Cronwell is best known for his role in hit movies and TV shows such as ‘Broadwalk Empire’, ‘The Green Mile’ and ‘American Horror Story’.
In Oliver Stone’s 2008 biopic ‘W’ he played former US President George H.W. Bush.
Mr Cromwell also used his interview with Variety to warn about the risk of fascism to America.
He controversially asserted: “This is nascent fascism.
“We always had a turnkey, totalitarian state. All we needed was an excuse and all the institutions were in place to turn this into pure fascism.”
In addition to his acting work Mr Cromwell is well known for his political activism.
He has previously been arrested for taking part in peaceful protests at SeaWorld and a New York gas plant.
He served three days in jail for the latter offence after refusing to pay a fine.