Loftus-Cheek has struggled for minutes under Sarri due to the form of Ross Barkley but he will play in the advanced midfield role tonight.
Sarri has made eight changes from the team which drew 2-2 with Manchester United on Saturday.
Eden Hazard is out with a back injury and replaced by Pedro in attack.
Kepa remains in goal but has a completely different back four in front of him.
Davide Zappacosta, Gary Cahill, Andreas Christensen and Emerson all come into the team.
N’Golo Kante and Jorginho are rested so Cesc Fabregas starts.
Chelsea: Kepa, Zappacosta, Cahill, Christensen, Emerson, Loftus-Cheek, Fabregas, Kovacic, Pedro, Giroud, Willian.