The NFC East clash sees the defending Super Bowl champions looking for their third win of the season having already lost three times this year.
The Giants, on the other hand, have started the season even worse having won just one of their opening five games.
New York will hope for Odell Beckham Jr fires tonight having impressed in defeat to Carolina Panthers last week.
The wide receiver had 131 receiving yards of the team’s 382 net yards through the air against the Panthers.
But he courted controversy this week after stating that he believes his career, which began in 2014, has been stagnated by the Giants.
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Beckham said: “I don’t feel like I’m being given the opportunity to be the very best that I can, to bring that every single day — and that’s really all I want to do, to bring that every single day.
“Since I’ve been here I’ve put up numbers, records have been broken and all those good things, not to say mean nothing to me, but I know they could have been double, or triple whatever they are now. That’s the part that bothers me.”
And here’s how you can watch if Beckham shines or stutters against the Eagles.
How to watch Giants vs Eagles LIVE on TV
The opening NFL game of Week 6 is live on Sky Sports with the match scheduled to begin at 1.20am.
Sky Sports Main Event, available on Sky channel 401, will show the game live with the match also on Sky Sports Action.
How to stream Giants vs Eagles LIVE online
Sky subscribers can live stream New York Giants vs Philadelphia Eagles online via SkyGo and the SkyGo app.
The match can be followed live on your desktop or laptop via the Sky Go app, which if you’re an existing customer, is also available on iOS and Android smartphone and tablet devices.
Sky Go is also available on a number of platforms including Amazon Fire devices, iPad, Mac computers and laptops, Playstation 3, PS4 and Xbox One.
The Sky Sports app, available to download on iOS and Android devices, will also be providing live text coverage and updates.
If you’re not currently a Sky Sports customer but can’t stand to miss out on the action, you can add the channels to your box via a NOW TV subscription.
Day passes, which let you add Sky Sports channels for 24 hours, start at £7.99 a day, with a weekly pass starting from £12.99, and no locking in to a contract.
NOW TV doesn’t even require a typical television to use, as it is also available on a NOW TV Box, Chromecast, PS4, PS3, Xbox One, Xbox 360, Roku, LG Smart TV, PC or Mac, and selected mobile and tablet devices.
American viewers can catch the action online by heading to WatchESPN.