Djokovic and Del Potro, both former US Open champions, will face each other for the fifth time at a Grand Slam event.
Djokovic holds a 14-4 head-to-head advantage over Del Potro, including 4-0 in Grand Slams.
Del Potro’s last win over Djokovic came in the first round of the Rio Olympics in 2016.
Both players are trying to win their third title of the season.
Del Potro’s last Grand Slam final appearance was in 2009 when he defeated Roger Federer.
Djokovic is appearing in an Open Era record-tying eighth US Open final and 23rd overall.
Del Potro has only lost one set (17-1) in six matches leading into the final and that came in the opening set tie-break of his quarter-final against Isner.
At least one member of the Big Four (Rafael Nadal, Roger Federer, Djokovic, Andy Murray) has reached the US Open final in 14 of the last 15 tournaments.
Novak Djokovic vs Juan Martin Del Potro LIVE
First Set (*denotes server)
Djokovic* 4-3 Del Potro
Djokovic holds to love. Looks the business so far.
Djokovic 3-3 Del Potro*
Both players serving excellently so far. A serve at 131mph sees him hold to 15.
Djokovic* 3-2 Del Potro
Good hold as he powers down some big second serves to keep Del Potro on the back foot.
Djokovic 2-2 Del Potro*
Pure power on the forehand from Del Potro makes it 15-0. And he ends the game with a backhand winner down the line.
Djokovic* 2-1 Del Potro
0-30 as Del Potro finishes at the net with a backhand volley. But Djokovic works the ball to Del Potro’s backhand and it breaks down twice.
Back-to-back big forehand from Del Potro takes it to deuce. But Djokovic escapes and fist pumps towards his support box.
Djokovic 1-1 Del Potro*
Del Potro is looking to get his big forehand into play at every opportunity. And wins the game with a huge winner down the line.
Djokovic* 1-0 Del Potro
The opening game goes to 40-30. But Djokovic gets off to a good start as Del Potro goes long with a backhand.
21:15: The players are warming up. Djokovic to serve first.
21:10: The players are having their pre-match interviews with host broadcaster ESPN. They will be out on court any minute now.
20:55: The men’s final will be under the roof on Arthur Ashe after heavy rain in New York.
20:45: The final of the women’s doubles has just finished and with the trophy presentation to come, the men’s final will be delayed.
20:30: Welcome to LIVE coverage of the men’s US Open final between Novak Djokovic vs Juan Martin Del Potro.