The hardline leftist is one of the government’s most vocal critics, and has repeatedly urged France to exit international organisations, including NATO, the IMF and the WTO.
Mr Mélenchon, leader of the far-left opposition La France Insoumise (France Unbowed) political party, told the French daily La Provence: “I want to turn the European elections into an anti-Macron referendum.”
Mr Macron is the “only person to defend [German Chancellor Angela] Merkel’s vision for Europe,” the veteran rabble-rouser said, adding that his party was strongly opposed to the idea of “building Europe by dismantling France”.
A fierce critic of the Macron administration and vocal eurosceptic, Mr Mélenchon has in the past called on France to quit NATO, the World Trade Organisation, the International Monetary Fund, and block European trade treaties with the United States and Canada.
The former presidential candidate has also floated the idea of a French exit from the bloc.
European political groups are already preparing for the EU election, with mainstream parties fearing, as in 2014, a poor voter turnout and a surge in support for politicians hostile to the European Union.
The next elections will take place in most countries on May 26, 2019.
Hard-left lawmaker Alexis Corbière, a member of La France Insoumise, echoed the words of Mr Mélenchon on Europe on Friday, saying: he He told France’s RTL radio: “Today’s Europe is Macron and Merkel’s Europe.
“Those who destroy work done on a national level will inevitably destroy work done on a European level.”
Mr Corbière lashed out at Mr Macron, saying that the “brutal” government’s economic reforms “locked people into a cycle of poverty”.
He said: “The Macron illusion has faded… Most people have realised that the [government’s] reforms benefit a wealthy minority.”
He also denounced the president’s “detestable rhetoric” and “contemptible remarks”.
Mr Macron has repeatedly fought off accusations of favouring the rich, after making good on a campaign promise to scrap France’s wealth tax – a symbol of social justice.
His move to replace the tax with a levy targeting only real estate in October last year earned him the nickname “president of the rich,” a label he has been struggling to shake off ever since.