Angela Merkel, 64, and second husband Prof Joachim Sauer have gone on a walking holiday in South Tyrol every year since 2008.
But the German Chancellor has pulled out of this year’s trip to stay in Berlin with her husband left to go walking on his own.
Mrs Merkel has cancelled the holiday due to “political commitments”, according to Italian news agency Ansa.
The Chancellor’s office said: “On the private appointments of the Chancellor, we give basically no information.”
German media has claimed Prof Sauer, 69, will instead holiday later this month in the Italian mountain village of Unterm Ortler with one of his sons from his first marriage.
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Rooms booked for the Chancellor’s security team have already been cancelled, according to Neue Südtiroler Tageszeitung.
Yesterday the couple celebrated Mrs Merkel’s 64th birthday at a dinner with friends in Berlin.
But amid the celebrations, Mrs Merkel has been faced with political turmoil in Germany from both her opposition and her government allies.
The German Chancellor has been fighting for her political life with her conservative bloc almost on the brink of collapse following furious rows over immigration.
German Interior Minister Horst Seehofer, from the Bavarian sister party of the Chancellor’s conservatives, takes a hard line on immigration and almost toppled the government this month in a row over migrant policy.
An Allensbach poll for the Frankfurter Allgemeine newspaper due to be published on Wednesday showed support for the conservative bloc dropping to 30.5 percent from 33 percent, its lowest since October 2010, while support for the anti-immigrant Alternative for Germany rose to 15 percent from 13 percent.
The survey found the recent migration dispute had helped turn migration into a dominant issue of concern among Germans, even though the refugee situation has not escalated.