The Front National leader has built her surging campaign around fierce criticism of the European Union.
She has vowed to renegotiate France’s membership with the Brussels club or leave it all together if she is successful in the looming French elections.
The MEP believes globalisation, promoted for decades by French politicians, has left neighbourhoods “no longer living a French life”.
“Wild globalisation has benefited some, but it’s been a catastrophe for most,’ she told CBS.
“A catastrophe which has ravaged the French economy, as jobs have faded away and immigrants have flooded in, many of them Muslim immigrants, from North Africa.
“They are draining resources, rejecting French values and transforming the culture.”
Polls suggest the nationalist leader is likely to win the first round of France’s election on April 23.
However, surveys also show she would lose the deciding final run-off in May to the centrist Emmanuel Macron.
Despite the odds against her, Ms Le Pen believes she can cash in on recent the rise of populism in the West.
She said: “They also said that Brexit wasn’t going to happen, that Donald Trump wasn’t going to be elected, wasn’t even going to be his party’s nominee.
“Well, they’re saying that less and less now. They are much more cautious, much more cautious now.”
Ms Le Pen has built her campaign around her fierce criticism of the European Union.
Ms Le Pen’s chances of winning the looming election were given a fresh boost on Monday when former prime minister Alain Juppe revealed he wouldn’t stand in the race to replace scandal-hit Francois Fillon.
Mr Fillon found himself in hot water over allegations that members of his family were paid taxpayers’ money for fictitious jobs.
The claims have seen him lose support within the centre-right party and in opinion polls.
A poll on Friday showed if Mr Juppe had become the new centre-right candidate, he would likely win the election’s first round in April, with Emmanuel Macron coming second – knocking anti-Brussels Ms Le Pen out of the race.