The earthquake sent panicked locals into a frenzy, wandering the streets in despair in the early hours of this morning.
The magnitude 6.1 quake hit 43km (27 miles) east of Oaxaca at a depth of 10km at 6.56GMT, the US Geological Survey said.
The epicentre was close to the city of Pinotepa Nacional, which has a population of 26,000.
The earthquake woke residents of Mexico City, with many people running into the streets, according to Reuters.
A stronger 7.2 magnitude earthquake rattled Oaxaca on Saturday, leaving a million homes without power but there were no direct reports of loss of life.
However, a helicopter carrying officials to the scene of the quake crashed in the in Santiago Jamiltepec on the way to the state and killed 14 people.
The earthquake shook buildings in the capitaL, sent tremors as far south as Guatemala and set off more than 1,520 aftershocks.
The southern state requested federal emergency funds on Sunday to supply food, shelter and health services in more than 30 municipalities battered by last week’s powerful quake in a region still reeling from temblors in September.
The quake, whose epicentre was 11 kilometers south of Pinotepa Nacional, Oaxaca, was felt in 11 states as well as Mexico City and lasted for more than a minute.
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