Mr McMaster addressed the issue of nuclear weapons development and propagations by the hands of rogue states like North Korea, Syria and Iran.
The US National Security Advisor said it was time to act internationally against the Iranian regime fomenting violence in the Middle East.
He said: “Now it’s time to address Syria’s flaws in the Iran deal and counter Iran’s destabilising activities, including its development and proliferation of missiles and its support for terrorist proxies and militants that fuel a destructive conflict across the Middle East.
“The Iranian regime foments this violence with support for commercial entities affiliated with Islamic revolutionary guards corps.
“As a matter of international security and moral conscience, we must stop doing business with IRGC affiliated interest, encourage the development of a true commercial sector in Iran and pressure the regime to respect the rights of its people.”
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On Thursday, French President Emmanuel Macron demanded Iran’s ballistic missile programme to be placed under international surveillance as the French president looks to take a tougher stance on Tehran.
Mr Macron said the use of “Iranian-linked missiles in Yemen and Syria” needed to be addressed.
His call comes as the Iran nuclear deal is precariously poised following Donald Trump’s threats to scrap the agreement.
The French leader said Paris, one of the signatories of the 2015 deal, wants to preserve the accord because nothing better has been tabled.
He said the international community needs “to put Iran under surveillance over its ballistic missiles”.
The French president said: “It’s indispensable for the security of the region and so we need a mechanism of sanctions and control adapted to that.”
Last month Donald Trump warned he will pull the deal – which regulates the way Tehran produces nuclear power – if the European countries involved don’t “fix the issues” within the agreement.