Mr Macron said France was doing everything it could to stop any illegal crossings into the UK and described Calais as a “dead end” for many people who have spent years on the road.
At the height of the migrant crisis, some 7,000 migrants set up a camp, dubbed the Jungle, at the Calais port.
Speaking on a visit to France’s northern port, Mr Macron said: “Calais has become an impasse.
“In no way will we let illegal routes to be developed here. In no way will we let a ‘Jungle’ spring up or an illegal occupation of the territory”.
The leader of France is due to meet Theresa May on Thursday where they will discuss the migrant problems in Calais.
It is also thought Mr Macron will call for Britain to do more to improve the migrant crisis around the port town and potentially ask Mrs May to take in more child refugees.
Mr Macron said the current Dublin rules, under which refugees are required to seek asylum in the first safe country they reach, were “unsatisfactory” and called for an “integrated” EU system to deal with the problem.
Gerard Collomb of the French Socialist Party said he wants the UK to pay more towards planned infrastructure improvements in the area.
According to the French government, there are up to 500 migrants living in Calais after the Jungle was shut down in 2016.
Mr Macron also visited the three new reception centres built for the migrants trying to enter the UK.
France is set to unveil a new migrant policy next month, which will include speeding up the application process for asylum seekers and a faster removal of those who have not been accepted.
Mr Macron said: “To stay in Calais and built makeshift shelters and even set up squats is a dead end. The alternative is clear; people can get to the reception centres where everyone’s case will be examined and those who have the right, given asylum in our country.”
The French government wants new immigration and asylum legislation to be discussed at the council of ministers in February.
The new laws will focus on controlling the flow of migrants, a better system to deal with the asylum-seeking process, tightening laws to remove people who in the country illegally and the integration of refugees.
Mr Macron met Calais mayor Natacha Bouchart and organisations working with migrants on Tuesday.