The Cavs are in a rich vein of form and are searching for their eighth win on the bounce.
LeBron James has been in irresistible form and he is hoping to become the first player in NBA history to shoot at least .400 from 3-point and .550 from the field in the same twice.
He’s averaged 28.5 points per game and almost nine assists to boot too.
However, it is unclear whether Cavs guard Derrick Rose will stay.
The 29-year-old has missed 12 of his side’s 19 games this season, including the past eight with a sprained ankle.
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He is reportedly re-evaluating his future, despite only signing a deal to join this campaign.
The 76ers could be without point guard Ben Simmons for the clash.
He missed only his first game of the season on Sunday as his side beat Orlando 130-111.
But his elbow is causing him some discomfort which could force him to sit it out.
How to watch Cleveland Cavaliers vs Philadelphia 76ers on TV?
Tonight’s action is scheduled to start at 12.30am GMT and will be shown live on BT Sport 1.
BT Sport is the exclusive home of the NBA in the UK for the 2017/18 season.
They will broadcast up to seven lives games per week throughout the regular season and the first and second rounds of the playoffs, as well as every game of the conference finals and NBA Finals.
How to watch Cleveland Cavaliers vs Philadelphia 76ers online?
If you’re unable to get in front of a TV, BT Sport customers are able to watch the game live via the app.
Alternatively you can sign up for the NBA League Pass with the option of a day pass.
The NBA League Pass lets you watch every NBA game depending on the package you select.
American viewers can catch the action online by also going for the NBA League Pass.