Based on the classic novel by Madeleine L’Engle, the movie stars Oprah Winfrey, Mindy Kaling and Reese Witherspoon among many other huge names.
Chris Pine, Gugu Mbatha-Raw, Zach Galifianakis, Storm Reid and Levi Miller also appear.
From the small screen, Scandal’s Bellamy Young and Girl Meets World’s Rowan Blanchard fill out smaller roles.
The Disney production will arrive on a wave of hype in early 2018, with thousands of retweets and Likes for its latest clip on social media.
“I’m so excited I could cry. Still have the original copy I bought with my allowance in 1982,” wrote one person.
“I’m just. Give me me a moment… AWIT was my f**king fave in elementary,” another said. “Lil 5th grde me prob didn’t totally comprehend a lot of the concepts.”
A third replied: “I’m choked up. This book saved me.
“It made me a better reader and a life long book worm and helped me deal with my sister’s illness. It was my warm safe place to hide for a while.”
Ava DuVernay has directed the movie, from Jennifer Lee’s screenplay.
DuVernay’s previous work includes Selma and the Oscar-winning 13th.
A Wrinkle In Time is out on March 9, 2018.