Panthers (6-3) have the best defence in the league and are in and around the play-offs.
The Dolphins (4-4) meanwhile sit just outside of the top six.
Dolphins are without Ja’Wuan James, who has been placed on injured reserve because of a hamstring injury.
Panthers’ three-time Pro Bowl tight end Greg Olsen, who is on injured reserve will work as a pundit for Fox Sports.
However, the Dolphins will need to be more clinical as they have managed just 14.5 points per game – the worst scoring offence this season in the NFL.
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How to watch Miami Dolphins vs Carolina Panthers on TV?
The final game of week 10 is live on Sky Sports Main Event on channel 401 with coverage starting at 1.15am today with the match scheduled to begin at 1:30am.
Sky Sports Action, available on Sky channel 408, will show the game live while Virgin Media customers can watch the action on channel 501.
How can I stream Miami Dolphins vs Carolina Panthers live online?
If you’re unable to get in front of a TV, Sky Sports customers are able to watch the game live via Sky Go.
American viewers can catch the action online by heading to WatchESPN.