The two men have a frosty relationship, with both players exchanging verbal blows ever since their controversial meeting in April.
Williams was withdrawn that night in Manchester with a cut to his eye in the 10th round – which has only added more intrigue to tonight’s rematch.
Wiliams was ahead on points at the time, which has led to theorists to ponder whether Smith really did accidentally clash heads with his opponent.
With current world champion Miguel Cotto set to call time on his career next month, tonight’s clash will make for blockbuster viewing.
What time does it start?
The bout will be held at the Metro Arena in Newcastle this evening.
The action on the night starts at 7.45pm.
How can I watch it?
Smith vs Williams will be shown live on BT Sport 1.
The fight can be live streamed on BT Sport’s official website and app for their customers.
Who is on the undercard?
Smith and Williams is undeniably the main event tonight.
But there are plenty of other exciting fights happening.
Thomas Patrick Ward will take on Sean Davis, while Josh Leather will tackle Glenn Foot.
Nathan Gorman and Mohamed Soltby both enter their fight with 100 per cent records – so something will have to give.
What is the full card?
Liam Smith (25-1-1) vs Liam Williams (16-1-1)
Thomas Patrick Ward (21-0) vs Sean Davis (13-1)
Josh Leather (12-0) vs Glenn Foot (21-2)
Nathan Gorman (10-0) vs Mohamed Soltby (13-0)
Jeff Saunders (11-0) vs Steven Lewis (14-0)
Mark Heffron (17-0) vs Lewis Taylor (19-4-1)
Joe Maphosa (2-0) vs Craig Derbyshire (5-23-3)
Kalam Leather (2-0) vs Michael Mooney (8-41-1)
Michael Watson (Debut) vs Hristo Yonev (8-41-1)