Georgie is a 42-year-old single mother and a garrulous fantasist, while Alex is a 75-year-old butcher who has settled for a loveless half-life of working and walking.
Playwright Simon Stephens delivers an unvarnished tale of two characters adrift in their own lives and is aided by a brace of intoxicating performances.
Cranham is a stolid presence, anchoring the production for Duff’s over-animated Georgie: “Do you find me exhausting but captivating?” she asks.
Yes and yes.
Bunny Christie’s antiseptic white set and Paule Constable’s colour-coded lighting leave almost everything to the performers, the walls moving in harmony with the mood.
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The “uncertainty” runs throughout as Georgie’s compulsive deceptions conceal an ulterior motive while Alex slowly unravels his knotted character to reveal a surprising generosity of spirit.
Their gentle, sedate tango at the conclusion suggests that this is not the beginning of the end.
It’s the end of the beginning.
Heisenberg The Uncertainty Principle at Wyndham’s Theatre, until January 6
Tickets: 0844 482 5120