Talking to Express.co.uk, Mr Di Maio said the European Union and its institutions need to change if they want to survive the uncertain European political climate.
Mr Di Maio said: “ If the European Union doesn’t change its regulations, it will die. I think it’s now the right political moment for the EU to reform. People have finally voted in France, in the UK, and in Germany. Excluding the Brexit results in England, national leaders can now start making decisions without fear of losing votes.
“Despite already having lost most of it because they didn’t address the issues. We want the EU to exist, but it must do so in a fair way inspired by its founding principles.”
The 5 Star Movement (M5S) politician was recently chosen to represent his party at the upcoming Italian election to select the Southern European country’s next prime minister in Spring 2018.
Mr Di Maio won the primary election during an online vote that saw 30,936 M5S supporters casting their preference, returning an 82 percent support for the young MP.
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The Prime Ministerial candidate entered politics in 2007, running for the first time in 2010 and entering Parliament in 2013 after the last political elections held in the country.
Enrico Letta was the last Italian Prime Minister to be democratically elected by the Italian citizens.
Successors Matteo Renzi and Paolo Gentiloni both took over the role bypassing the electoral system.
Born in 1986, Mr Di Maio is the youngest ever Vice-President of the Chamber of Deputies starting his mandate aged 26.
In perfect synch with his party line, Mr Di Maio is planning to run on a manifesto promising a swift reform of the overly-bureaucratic Italian legislative system.
The changes suggested include a renegotiation of Italy’s relationship with the European Union, plagued with defects and in need of modernisation according to Mr Di Maio.
He said: “We want to change the EU, we want to modify a series of treaties, rules that don’t work.
“The monetary union has many defects. Before letting Italians decide whether they want out or not we need to rectify these defects. In its first year, an M5S Government will focus on EU negotiations to try to bring together all European leaders that have become critical of the rules of the game
On the national level, the Italian politician plans to prioritise legislative reform to get rid of “unnecessary” laws that fill Italy to excess.
He said: “Here in Rome, we make one law every two and a half days. That’s summed up to the 25,000 pre-existing laws, the ones created by the single regions and EU law.
“Every day, if not half a day, an Italian citizen is hit by a new law. This is reducing the country to hell. Everything is blocked, and when we have a problem we don’t know who has to resolve it and which law applied to it.”
According to latest Index Research polls, Mr Di Maio’s M5S is leading the Italian political scene with 26.6 percent of preference against the governing Partito Democratico (PD), stalled at 25.5 percent.
Italy is expected to go to the polls in March 2018 but a date has yet to be announced.