The Arizona Cardinals (1-1) meet the Dallas Cowboys (1-1) at the University of Phoenix Stadium in Glendale, Arizona.
The match comes after a hugely controversial weekend in the NFL, with more than 150 players protesting against the national anthem.
Donald Trump has staunchly condemned those players protesting but there could be more to come when Arizona and Dallas play tomorrow morning.
And if you want to catch the action, here is how you can watch online and on TV.
How can I watch the Arizona Cardinals vs Dallas Cowboys live on TV?
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This NFL match will be televised live on Sky Sports with the match kicking off at 1.30am – coverage starts at 1.15am.
Sky Sports Action, available on Sky channel 408, will show the game live while Virgin Media customers can watch the action on channel 508.
How can I stream Arizona Cardinals vs Dallas Cowboys live online?
If you’re unable to get in front of a TV, Sky Sports customers are able to watch the game live via Sky Go.
When are the next NFL London games?
UK fans are being treated to a total of four NFL games in the London Series, three after the Baltimore Ravens’ win against the Jacksonville Jaguars at Wembley yesterday.
October 1, New Orleans Saints vs Miami Dolphins (2.30pm BST) – Wembley Stadium
October 22, Arizona Cardinals vs LA Rams (6pm BST) – Twickenham Stadium
October 29, Minnesota Vikings vs Cleveland Browns (1.30pm GMT) – Twickenham Stadium
The series sees a London debut for three of the eight teams taking part with the Ravens, Browns and Cardinals all making their first appearance across the Atlantic.