There are more than a hundred different types of liver disease, and the condition affects two million people in the UK.
However, the rate of people dying varies greatly across the UK, according to new data.
Public Health England found that in some parts of England it was almost eight times higher than in other areas.
Premature mortality rates – meaning dying before 75 – ranged from 3.9 per 100,000 in South Norfolk to 30.1 per 100,000 in Blackpool.
This gap has widened over the past decade, and the data reveals great health inequalities within England.
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Close behind Blackpool with highest liver disease mortality rates were North Manchester and Wolverhampton.
With the lowest mortality rates, South Norfolk was joined by Aylesbury Vale and Barnet.
The condition accounts for 12 per cent of the deaths in men aged between 40 and 49.
It is almost entirely preventable.
Alcohol, obesity and Hepatitis B and C are responsible for up to 90 per cent of cases.
“Chronic liver disease is a silent killer of young adults, creeping up and showing itself when it’s often too late,” said Professor Julia Verne, head of clinical epidemiology at Public Health England.
“We hope local health professionals will make the most of this rich data source to inform how they reduce the burden of liver disease in their areas.”
The data shows that the majority of the higher rates are in areas with more deprivation.
In the most deprived fifth of the country, people die from the disease nine years earlier than people in the most affluent fifth.
It is hoped the data will help health professionals better allocate resources to combat liver disease.
Symptoms, such as yellowish skin and eyes and swollen ankles, can take 20 years to show.