Nadal battled past Argentina’s Juan Martin del Potro 4-6 6-0 6-3 6-2 and is on the brink of a 16th slam title.
Anderson took apart Pablo Carreno Busta in four sets to secure his place on the Arthur Ashe court today.
Stephens beat Keys 6-3 6-0 in the women’s final to claim her first career Grand Slam.
Speaking after the final Stephens said: “I should just retire now. I told Maddy, I’m never going to be able to top this.”
Meanwhile, Jamie Murray and Martina Hingis won another Grand Slam mixed doubles title by beating Chan Hao-Ching and Michael Venus 6-1 4-6 10-8.

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US OPEN LIVE: All the build up to Nadal vs Anderson and reaction from Stephens and Murray wins
Nadal vs Anderson form
13:15: Let’s take a look at the form guide for Nadal and Anderson…
1-Rafa Nadal
Rafa Nadal has raised the intensity of his game as the U.S. Open has progressed and was at his ruthless best against Juan Martin del Potro in the semi-final.
After an early wobble, he switched gears to prevail and move within touching distance of his 16th grand slam title.
With four titles this year, including a grand slam at Roland Garros, Nadal has the momentum going into the match and with a comprehensive 4-0 winning record against the South African, will be heavy favourite to lift his third U.S. Open title.
28-Kevin Anderson
Wielding his monster serve to devastating effect, Anderson beat Spain’s Pablo Carrena Busta 4-6 7-6 6-3 6-4 in the semi-finals to reach his first grand slam final at the age of 31.
After overcoming a hip injury that threatened his 2017 campaign, he has made his mark at Flushing Meadows with his resolve and dedication.
His path to the final was eased by injuries to top players but he has grabbed his chance with both hands and will deservedly bid to become the first South African to win a grand slam singles title in over 30 years.
Against Nadal, one of the game’s best returners, hustlers and retrievers, the 6ft 8in (2.03m) South African will need to go for his shots from the outset to try to delay his opponent from getting comfortable, otherwise it could be a very quick final.
He will need to keep the points short and avoid getting dragged into taxing rallies that Nadal will invariably win.
Nadal will be more than ready for Anderson to swing for the fences, but it will probably be the South African’s best chance of snatching a set or two to pressure the Spaniard and provide a genuine contest.
Murray wins mixed doubles title
12:00: Jamie Murray as paid tribute to partner Martina Hingis after the pair won the US open mixed doubles title on Saturday.
Brit Murray and his Swiss partner Hingis beat Chan Hao-Ching and Michael Venus 6-1 4-6 10-8.
Hingis won the singles title in New York 20 years ago.
Murray said: “She’s an amazing player, she’s had such a great career.
“It’s been a lot of fun, we’ve won a lot of close tennis. It just shows how fine the margins are. Hopefully we play more.”
Hingis has confirmed that if she is to play the Australian Open next year it will be alongside Murray.
Stephens beats Keys
11:30: Sloane Stephens roped to victory over Madison Keys in the women’s final last night.
Stephens won the all-American affair 6-3 6-0 during a clinical display of tennis on Arthur Ashe.
“Madison is one of my best friends on tour,” Stephens said. “I wouldn’t have wanted to play anyone else. I told her that I wished it could have been a draw.
“I know if it had been the other way round she would have supported me so that is what I am going to do for her. That is what real friendship is.
“When I was 11 years old my mum took me to an academy and one of the coaches told her that I would be lucky to be a division II player and get a scholarship.
“I don’t think parents get enough credit. Parents, if you kids want to do something enough, don’t give up on them.”
Nadal vs Anderson
11:00: Rafael Nadal takes on Kevin Anderson in the US Open men’s final tonight but the Spaniard is not thinking about Grand Slam no 16.
Nadal, the US Open champion in 2010 and 2013, said: “For me, what is more important, more than winning slams, is to be happy.
“I am happy if I am healthy, and happy if I feel competitive and that’s what happened this year.
“It’s a very tough one. He’s a huge player with an unbelievable serve.”
Anderson has previewed the final saying: “Nadal is one of the greatest competitors.
“I really need to be dominant and control proceedings as much as possible.”