First up on Arthur Ashe is Venus Williams taking on Sloane Stephens, before Coco Vandeweghe battles Madison Keys.
Not since Tracy Austin, Martina Navratilova, Chris Evert and Barbara Potter reached the last four in 1981 has the host nation managed such dominance.
So who is the favourite with the bookies to win the US Open?
Sky Bet currently have Keys as the favourite at 7/4, closely followed by Wiliams at 5/2.
The bookmakers reckon Vandeweghe (3/1) and Stephens (9/2) are the outsiders to lift the trophy.
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US OPEN LIVE: FOLLOW ALL THE LATEST NEWS FROM FLUSHING MEADOWS
Ninth seed Williams, 37, is the oldest semi-finalist at any Grand Slam since Martina Navratilova at Wimbledon in 1994.
“It’s such a wonderful feeling, because you put in so much work to be able to succeed at these moments,” said Williams.
“It has been a great two weeks for American tennis, seeing all the American players in the draw and all of them advancing so deep and competing so well.”
US Open results – Day 11
Venus Williams v Sloane Stephens – result to follow
Coco Vandeweghe v Madison Keys – result to follow