The 63-year-old has held the northeastern district Vorpommern-Rügen – Vorpommern-Greifswald I, which borders the Baltic Sea, since she entered parliament in 1990.
However the CDU/CSU leader actually grew up in Templin – a town due south and in the next state.
Now Leif-Erik Holm of the hard-right Alternative for Germany (AfD) has vowed to “send Merkel home” in the upcoming elections.
A self-styled “local boy”, Mr Holm says Mrs Merkel is no longer representing people from the very area she represents.
He said: “Angela Merkel was very popular here, that’s true. But times have changed.”
The 47-year-old claims that the chancellor has dramatically hampered her chances over her decision to open the borders to Germany to one million migrants, which he claims may cost her the result.
He added: “People are asking ‘what is she doing?’
“Merkel has failed in a lot of people’s eyes and they are looking for an alternative.”
The Chancellor won the constituency with 56 percent of the vote at the last national election, in 2013.
Now, the AfD is emboldened in the district after beating her conservatives into third place in the wider northeastern region of Mecklenburg-Vorpommern last year.
AfD co-chair Frauke Petry says the constituency is “a prestige target” for the party.
However the Europhile made it clear this was her turf, after she spent a full day touring the district on Thursday – telling voters she promised no repeat of the 2015 refugee influx.