A huge part of the 1,500-strong crowd whistled and booed Chancellor Merkel as she attempted to deliver an election campaign speech in Brandenburg City.
Footage shows a large group of people angrily yelling “get out, get out,” drowning out Mrs Merkel’s voice.
The demonstration was organised by members of the Alternative für Deutschland (AfD) and National Democratic Party (NDP).
The CDU election campaign team are well used to boos during their tour of Germany one month before the September 24 election.
While in Annaberg-Buchholz she was branded a “traitor of the nation” due to her ‘open border policy’ and was once again heavily screamed at.
Since 2015, Germany has welcomed nearly one million immigrants and refugees.
Anti-immigration campaigners from the AfD have been protesting against Ms Merkel since she hit the campaign trail in early August.
Despite the demonstration against her, polls show Mrs Merkel will likely win the election this coming September.
Martin Schulz, the former president of the European Parliament and the closest opponent to the Chancellor, recently launched a barrage of personal attacks against Mrs Merkel in a desperate attempt to garner support.
Mr Schulz accused Mrs Merkel of being “disconnected from reality” and “aloof”.