The market for herbal supplements is in rude health. However, there are growing concerns related to the safety and toxicities of these medicines. “Despite popular belief that the consumption of natural products is harmless, herbs might cause injury to various organs, particularly to the liver, which is responsible for their metabolism in the form of herb-induced liver injury (HILI),” researchers wrote in a study published last year.
They sought to identify herbal products associated with HILI and describe the type of lesion associated with each product.
HILI describes an adverse reaction to herbal medicines.
Searches were run and studies were retrieved from the electronic databases Scopus, Web of Science, MEDLINE, BIREME, LILACS, Cochrane Library for Systematic Reviews, SciELO, Embase, and Opengray.eu.
In the final analysis, 446 references were included, with a total of 936 cases reported.
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Research recently carried out in Latin America found the most common causes to be Camellia sinensis, which is the active compound of green tea, and Herbalife products, which contain a mixture of herbs (although it is not known which herb[s] can cause liver injury).
“These herbal products are perceived to be innocuous and healthy, and are often thought to be beneficial for weight loss, but that is not the case,” the researchers wrote.
They can induce autoimmunity and frequently cause injury to the liver.
Interestingly, these liver injuries are not caused by ingesting a set amount of these herbal products, researchers have found. These injuries are known as idiosyncratic reactions, which are not related to the quantity of an herbal product. They are unexpected reactions to usual portions of the product. Any person with any amount may be susceptible to developing such an injury.