Simon Middleton and Greg McWilliams have named their teams for this lunchtime kick-off.
England have made three changes to their starting XV. Leanne Infante, who wins her 50th cap, comes in at scrum-half and Holly Aitchison starts at inside centre. Zoe Aldcroft is at lock to make her first appearance of the tournament.
There is a positional change too with Helena Rowland at full-back.
England: Helena Rowland; Lydia Thompson, Emily Scarratt, Holly Aitchison, Jess Breach; Zoe Harrison, Leanne Infante; Vickii Cornborough, Lark Davies, Sarah Bern, Zoe Aldcroft, Abbie Ward, Alex Matthews, Marlie Packer, Sarah Hunter (captain).
Replacements: Amy Cokayne, Hannah Botterman, Maud Muir, Rosie Galligan, Poppy Cleall, Natasha Hunt, Amber Reed, Ellie Kildunne.
Ireland, meanwhile, have made six changes to their starting line-up. Molly Scuffil-McCabe will win her first start and she joins Aoife Doyle and Eimear Considine in the back three.
Sene Naoupu and Enya Breen make up a new centre pairing, while in the forwards Aoife McDermott starts for injured Sam Monaghan.
Ireland: Molly Scuffil-McCabe; Aoife Doyle, Sene Naoupu, Enya Breen, Eimear Considine; Nicole Cronin, Kathryn Dane; Linda Djougang, Neve Jones, Christy Haney, Nichola Fryday (captain), Aoife McDermott, Dorothy Wall, Edel McMahon, Hannah O’Connor.
Replacements: Emma Hooban, Chloe Pearse, Katie O’Dwyer, Grace Moore, Maeve Óg O’Leary, Aoibheann Reilly, Michelle Claffey, Niamh Byrne.