No surprises in either XI. David de Gea, demoted to Europa League goalkeeping duties, replaces Dean Henderson, and Marcus Rashford is preferred to the in-form Mason Greenwood on the right. Chris Smalling and Henrikh Mkhitaryan both start for Roma.
Manchester United (4-2-3-1) de Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Rashford, Fernandes, Pogba; Cavani.
Substitutes: Grant, Henderson, Bailly, Mata, Greenwood, Amad, James, Telles, Matic, Williams, van de Beek, Tuanzebe.
Roma (3-4-2-1) Pau Lopez; Smalling, Cristante, Ibanez; Karsdorp, Diawara, Veretout, Spinazzola; Pellegrini, Mkhitaryan; Dzeko.
Substitutes: Mirante, Fuzato, Villar, Santon, Mayoral, Kumbulla, Carles Perez, Bruno Peres, Ciervo, Darboe.
Referee Carlos del Cerro Grande (Spain).