Justin Tipuric has failed to recover from his bang on the head vs Georgia, and so Wayne Pivac shows his faith in James Botham by moving the young Cardiff man across to the openside to complete a new look back row with Shane Lewis-Hughes and Taulupe Faletau. Louis Rees-Zammit and Johnny Williams keep their places, as does Jake Ball who will partner record breaker Alun Wyn jones at lock.
Meanwhile, there’s raised eyebrows aplenty at the starting berth for Lloyd Williams at scrum-half, a decent technician but not obviously near international standard lately.
Eddie Jones makes one enforced replacement as Ollie Lawrence’s injury sees George Ford return to the starting line-up. Although, this probably would have happened anyway. Man of the series so far, Maro Itoje, continues his partnership with Joe Launchbury and it’s another 6-2 bench for England with the mercurial Jack Willis ready to appear at some point.
Wales: Leigh Halfpenny; Louis Rees-Zammit, Nick Tompkins, Johnny Williams, Josh Adams; Dan Biggar, Lloyd Williams; Wyn Jones, Ryan Elias, Samson Lee, Jake Ball, Alun Wyn Jones (capt), Shane Lewis-Hughes, James Botham, Taulupe Faletau.
Replacements: 16 Elliot Dee, 17 Rhys Carre, 18 Tomas Francis, 19 Will Rowlands, 20 Aaron Wainwright, 21 Rhys Webb, 22 Callum Sheedy, 23 Owen Watkin.
England: Elliot Daly; Jonathan Joseph, Henry Slade, Owen Farrell, Jonny May; George Ford, Ben Youngs; Mako Vunipola, Jamie George, Kyle Sinckler, Maro Itoje, Joe Launchbury, Tom Curry, Sam Underhill, Billy Vunipola.
Replacements: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Will Stuart, 19 Jonny Hill, 20 Ben Earl, 21 Jack Willis, 22 Dan Robson, 23 Anthony Watson.