The hosts Italy have made one change from the team that lost in Dublin last week, with Matteo Minozzi coming in at full-back.
For England, the scrum-half Ben Youngs wins his 100th cap. Exeter’s Jonny Hill makes his debut at lock after a stellar domestic season, with his club mate Henry Slade lining up at No 12, in the centre alongside Jonathan Joseph. Owen Farrell is back at No 10.
15-Matteo Minozzi, 14-Edoardo Padovani, 13-Luca Morisi, 12-Carlo Canna, 11-Mattia Bellini, 10-Paolo Garbisi, 9-Marcello Violi, 1-Danilo Fischetti, 2-Luca Bigi, 3-Giosue Zilocchi, 4-Marco Lazzaroni, 5-Niccolo Cannone, 6-Sebastian Negri, 7-Braam Steyn, 8-Jake Polledri. Replacements: 16-Gianmarco Lucchesi, 17-Simone Ferrari, 18-Pietro Ceccarelli, 19-David Sisi, 20-Johan Meyer, 21-Maxime Mbanda, 22-Guglielmo Palazzani, 23-Federico Mori
15-George Furbank, 14-Anthony Watson, 13-Jonathan Joseph, 12-Henry Slade, 11-Jonny May, 10-Owen Farrell, 9-Ben Youngs, 1-Mako Vunipola, 2-Jamie George, 3-Kyle Sinckler, 4-Maro Itoje, 5-Jonny Hill, 6-Tom Curry, 7-Sam Underhill, 8-Billy Vunipola. Replacements: 16-Tom Dunn, 17-Ellis Genge, 18-Will Stuart, 19-Charlie Ewels, 20-Ben Earl, 21-Dan Robson, 22-Ollie Lawrence, 23-Ollie Thorley
Referee: Pascal Gauzčre