The hospital will also be welcoming three new F1 doctors to the team; Josh Hudson (Trieve Blackwood-Cambridge) and Jeong Soo-Han (Chan Woo Lim) and Skylar Bryce (Phoebe Pryce).
Psych nurse Lucky Simpson played by Vineeta Rishi also joins, brought in by Chairman of the Board Michael Townsend to help the hospital recover from the COVID crisis.
Kate Oates, Head of Continuing Drama at BBC Studios, says: “I’m delighted to have Holby back on our screens, and can’t wait to see how recent months have impacted on our heroes of AAU, Keller and Darwin.
“Our hospitals have rarely been more important to us as a nation, and I’m excited to see that reflected in our drama – along with stories of love, loss and betrayal, plus some exciting new characters, and a returning favourite…”
Holby City returns to BBC One at November 10 at 8pm.