The first-ever evidence for a dinosaur that lived with a malignant, spreading caner has been discovered in a 77 million-year-old fossil, a study has reported.
Experts found the bone cancer — an osteosarcoma — in a horned plant-eating dinosaur, Centrosaurus apertus, that lived in Canada during the Cretaceous Period.
The lower leg bone — which was found in Alberta’s Dinosaur Provincial Park in 1989 — had originally been thought to have become malformed by a fracture healing.
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The first-ever evidence for a dinosaur that lived with a malignant, spreading cancer has been discovered in a 77 million-year-old fossil, pictured, a study has reported
Palaeontologist David Evans of the Royal Ontario Museum noted the bone’s unusual properties during a visit to the Royal Tyrrell Museum in Drumheller, Canada, in 2017 — and set out with colleagues to analyse it with state-of-the-art medical techniques.
The team — which included specialists in the fields of pathology, orthopaedic surgery and radiology — approached their diagnosis of the bone’s condition in exactly the same way that doctors would investigate a tumour in a human.
The team re-evaluated the bone and approached the diagnosis similarly to how it would be approached for the diagnosis of an unknown tumour in a human.
‘Diagnosis of aggressive cancer like this in dinosaurs has been elusive and requires medical expertise and multiple levels of analysis to properly identify,’ said paper author and pathologist Mark Crowther of the McMaster University in Ontario.
‘Here, we show the unmistakable signature of advanced bone cancer in 76-million-year-old horned dinosaur — the first of its kind. It’s very exciting.’
After carefully examining, documenting and casting the bone, the team performed high-resolution computed tomography (CT) scans of the fossil — before viewing thin slices of the bone under a microscope to study it at the cellular level.
Comparisons were also made between the cancerous bone and a normal lower leg bone, or fibula, from another dinosaur of the same species, as well as a fibula from a human with a confirmed case of osteosarcoma.
The researchers also used powerful three-dimensional CT reconstruction tools to visualise the progression of the cancer throughout the bone.
The team said that the fossilised bone belonged to an adult dinosaur with an advanced stage of the cancer that had likely invaded its other body systems.
Despite this, however, the specimen was found in a massive bone bed, suggesting that the Centrosaurus died as part of a large herd that was struck down by a flood.
Experts found the bone cancer — an osteosarcoma — in a horned plant-eating dinosaur, Centrosaurus apertus (pictured, with the affected bone highlighted) that once lived in Canada
The shin bone shows aggressive cancer at an advanced stage,’ said Dr Evans.
‘The cancer would have had crippling effects on the individual and made it very vulnerable to the formidable tyrannosaur predators of the time.’
‘The fact that this plant-eating dinosaur lived in a large, protective herd may have allowed it to survive longer than it normally would have with such a devastating disease.’
Osteosarcoma is a bone cancer that usually occurs in the second or third decade of life — and manifests as an overgrowth of disorganised bone that spreads rapidly and can affect other organs including, most commonly, the lungs.
It is the same type of cancer that afflicted Canadian athlete Terry Fox and led to the partial amputation of his right leg prior to Fox’s heroic Marathon of Hope in 1980.
After carefully examining, documenting and casting the bone, the team performed high-resolution computed tomography (CT) scans of the fossil — before viewing thin slices of the bone under a microscope to study it at the cellular level, as pictured
‘It is both fascinating and inspiring to see a similar multidisciplinary effort that we use in diagnosing and treating osteosarcoma in our patients leading to the first diagnosis of osteosarcoma in a dinosaur,’ said paper author Seper Ekhtiari.
‘This discovery reminds us of the common biological links throughout the animal kingdom and reinforces the theory that osteosarcoma tends to affect bones when and where they are growing most rapidly,’ the McMaster University surgeon added.
Establishing links between human disease and those of the past will help build an understanding of the evolution and genetics of various conditions, Dr Evans said.
Furthermore, he added, evidence of many other diseases that we have in common with the dinosaurs and other extinct animals may be sitting in museum collections across the globe — ready to be revealed using modern analytical techniques.
The full findings of the study were published in the journal The Lancet Oncology.
WHAT IS OSTEOSARCOMA?
Osteosarcoma is the most common type of bone cancer, usually diagnosed in teenagers and young adults.
It occurs when the cells that grow new bone form a cancerous tumor.
The cause of the cancer is unknown but it is thought to be related to rapid bone growth, such as adolescence.
Most tumors usually develop around the knee, either in the lower part of the thighbone or the upper part of the shinbone.
If the cancer has not spread, the long-term survival rate is between 70 and 75 percent.
If osteosarcoma has already spread, such as to the lungs or other bones at diagnosis, the long-term survival rate is about 30 percent.
- Bone pain (in motion, at rest, or when lifting objects)
- Bone fractures
- Limitation of motion of joints
There are a few treatment options for osteosarcoma.
Often administered before surgery, chemotherapy uses drugs that help shrink and kill cancerous cells. The length of treatment varies and may depend on whether the cancer has spread to other parts of the body.
In most cases, surgeons can save the cancerous limb. The tumor and surrounding bone are removed and the missing bone is replaced with an artificial one.
A rotationplasty is a procedure in which the bottom of the femur, the knee, and the upper tibia are surgically removed. The lower leg is then rotated 180 degrees and attached to the femur.
Sources: Macmillan and Healthline