Ridden by 17-year-old Jack Tudor, the 18-1 shot held off a late challenge from Walk in the Mill, with a fading Tiger Roll having to settle for fourth place.
Using the latest CGI technology and special algorithms, the race was shown as live on UK terrestrial broadcaster ITV, with 40 runners bidding for virtual glory.
Tiger Roll, with jockey Davy Russell, triumphed at Aintree in 2018 and 2019, and had been hoping to emulate the legendary Red Rum with a third victory in the grueling four-mile race (6.4km) with 30 challenging fences until the decision to cancel the race on March 16.
In the CGI version, Tiger Roll looked to have every chance of victory after shock frontrunner Aso took a heavy fall with two fences remaining, but fell away under top weight in the long run in to the finishing post at Aintree.
Tudor, who rode Potters Corner to victory in the Welsh Grand National last year, would have been the youngest winner of the Grand National since 1938 if a real race had matched the virtual one.
Previous computer simulations of the Grand National have proved surprisingly accurate given the unpredictability of the race, with the 2018 version won by subsequent winner Tiger Roll.
Potters Corner trainer Christian Williams had been targeting Aintree success after the Welsh Grand National victory but must now wait a year to see if it can become a reality.
“I’m delighted, it’s great and great to cheer everyone up in tough times – – I think even people from outside of racing were tuned in,” Williams said.
“It was something for people to cheer on, people are stuck in their houses and it probably got a good viewing. It was something to watch together and have a bit of banter leading up to it.”
Limited betting was allowed on the race, with a maximum stake of £10 (12 USD), with bookmakers donating the proceeds to National Health Service charities.
Earlier, a Champion of Champions race was run, resulting in victory for Red Rum, a three-time winner in the 1970s, with 19th century hero Manifesto second and Tiger Roll in third.