The plane was believed to be a Boeing 737. Local news agency Tasnim News Agency reported that the plane was attempting to land at the time. Iran affairs correspondent, Ali Hashem for the BBC reported the incident on Wednesday morning.
Iranian Fars News Agency said the plane suffered technical problems then went down after take off from Iran’s Imam Khomeini airport in Tehran.
Preliminary reports suggest the plane was en route to the Ukranian capital of Kyiv.
It is unclear whether the crash is related to the escalating tensions between the US and Iran.
The terrifying report comes just days after Iranian President Hassan Rouhani was accused of threatening threatening the US with another Lockerbie-style terrorist attack by Middle East experts.
He said in a tweet: “Those who refer to the number 52 should also remember the number 290.
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“Never threaten the Iranian nation.”
The tweet is in reference to when the US Navy accidentally shot down an Iranian passenger jet in the Persian Gulf in July 1988.
The horrific incident took the lives of 290 people.
Some Middle East experts have taken Rouhani’s tweet as a veiled reference to the Lockerbie attack.
The Lockerbie attack saw a bomb destroy a Pan Am flight over Scotland in 1988, killing 270.
The attack was just months after the shooting down of flight 655.
Libya was previously blamed for the attack, however, some experts believe Tehran could have played a role in the attack.
Middle East researcher Kyle Orton tweeted: “The accidental shoot-down of Iran Air Flight 655 in 1988 convinced Khomeini to accept the ceasefire in the Iran-Iraq War.
“It has long been suspected that the downing of Pan Am Flight 103 in Lockerbie five months later was Iran’s revenge.
“Rouhani seems to be taking responsibility.”