Manchester United find themselves in the bottom half of the Premier League table after six games.
The Red Devils have won just twice and will be looking to bounce back from the 2-0 defeat to West Ham last time out.
Arsenal have fared just slightly better this season, occupying eighth place in the table, three points ahead of United.
The Gunners came behind from behind twice to beat Aston Villa 3-2 in their last league outing.
What has been said?
Man Utd manager Ole Gunnar Solskjaer: “We are looking forward to it.
“I’ve watched Unai Emery over many years, and system-wise he can come with any shape, he knows it all.”
Arsenal boss Unai Emery: “Solskjaer has experience, he was a player at Manchester United, he knows the club perfectly, he knows the high competition, the high level and he has now very good players.
“His challenge is also to achieve the consistency and performances that will get them in the top four.”
What time does Man Utd vs Arsenal kick-off?
The Premier League clash gets underway at 8pm BST.
Can I listen to Man Utd vs Arsenal on the radio?
BBC Radio 5 Live will have live commentary of the match.
Fans can also listen to coverage online via the BBC website.
Earlier this year the broadcaster announced it had secured radio rights for the Premier League for another three seasons.
BBC Sport director Barbara Slater said of the deal: “Live radio coverage of the Premier League is a key element of the BBC’s audience offer for football fans.
“The quality of our production, commentary, analysis and presentation is unrivalled and it’s something we are immensely proud of.”