Defending champion Novak Djokovic is in action on day one against Roberto Carballes Baena.
Serena Williams faces Maria Sharapova on the Arthur Ashe Stadium at around midnight UK time in the standout match of the day.
Roger Federer will be last on court against Indian player Sumit Nagal.
Johanna Konta, Dan Evans and Cameron Norrie all represent Britain on day one as well.
US Open order of play: Full Day one schedule and results
Arthur Ashe Stadium – 5pm (BST) start time
Zarina Diyas vs Ashleigh Barty [2]
Novak Djokovic [1] vs Roberto Carballes Baena
Not before 12am
Serena Williams [8] vs Maria Sharapova
Roger Federer [3] vs Sumit Nagal
Louis Armstrong Stadium – 4pm start time
Tereza Martincova vs Karolina Pliskova [3]
Prajnesh Gunneswaran vs Daniil Medvedev [5]
Saisai Zheng vs Venus Williams
Not before 12am
Stan Wawrinka [23] vs Jannik Sinner
Misaki Doi vs Madison Keys [10]
Grandstand – 4pm start
Marco Trungelliti vs Kei Nishikori [7]
Angelique Kerber [14] vs Kristina Mladenovic
Sam Querrey vs Juan Ignacio Londero
Sofia Kenin [20] vs CoCo Vandeweghe
Court 17 – 4pm start
Johanna Konta [16] vs Daria Kasatkina
Fabio Fognini [11] vs Reilly Opelka
Elina Svitolina vs Whitney Osuigwe
Not before 10pm
Taylor Fritz [26] vs Feliciano Lopez
FOLLOW ALL THE ACTION FROM THE US OPEN AT FLUSHING MEADOWS BELOW