That is according to Goffin’s coach Thomas Johansson.
Medvedev is the hottest player in the men’s game at the moment after reaching his third ATP final of the summer.
The Russian had been a finalist at the Citi Open and Rogers Cup prior to arriving in Cincinnati and he earned a big win over Novak Djokovic on Saturday.
But Goffin is also playing well as he aims to bounce back from an injury-hit 2018 season.
The Belgian has never won a Masters 1000 event but enjoys playing in Cincinnati having reached the semi-finals last year.
Last month, the two men played out a gruelling five-set battle at Wimbledon with Goffin coming out on top after three hours and 31 minutes.
Speaking ahead of today’s final, Johansson assessed Goffin’s chances and made clear that going toe-to-toe with Medvedev from the baseline would not be the right way to win.
“He’s by far the hottest guy on the tour right now. He made finals in Washington, finals in Montreal and now a third final in a row,” he told Amazon Prime.
“He’s playing unbelievable but what we learned from that match is that they will most likely kill each other today.
“That’s what I told him in Wimbledon. I said prepare for a long one and it was a battle [as] David came back from a break down in the fifth.
“The most important thing today is not to try to out-him because it is impossible and everybody could see that against Novak.
“Novak is the best guy in the world from the baseline but he’s impossible to out-hit from the baseline.
“So today we have to find some other strategies.
“We tried at Wimbledon to hit him out of the baseline and it was impossible.
“So we need to use the slice a lot. We need to use height a lot. We need to use a little bit of drop shots when the opportunity is there and then I think we have a good chance.
“But I think Medvedev is by far the favourite. We are the underdog but we like that.“