The best DNA testing kits for 2019 – CNET

23andMe

• Price: $99 or $199 with health info (plus $9.95 shipping)
• Tests: Autosomal (see what this means), Y-DNA, mtDNA, Health
• Match Database: 8 million
• Autosomal SNPs tested: 650,000

Named for the 23 chromosomes found in human cells, 23andMe offers a battery of tests, including some that analyze health risks. (It was these tests that attracted attention from the FDA.)

23andMe earns points for the depth of its medical tests, as well as the size of its match database. Purchasers of this test should note that the basic DNA test is $99 but that medical results cost another $99.

The added expense may be worth the money; the additional information includes genetic health risk information, wellness reports, trait reports, and carrier status reports, which indicate whether a particular DNA profile may be a genetic carrier of a disease or disability.

Your DNA information is gathered using saliva capture, which, once analyzed, is stored forever on 23andMe’s servers. The service also provides for a chromosome browser and comparison, as long as any possible matches approve your access. The service’s matrilineal and patrilineal line testing can geolocate your ancestry DNA in more than 1,000 regions. 

(Appropriate for a genomics company, 23andMe’s executive ranks contain some interesting familial relationships: CEO and co-founder Anne Wojcicki is the former wife of Google co-founder Sergey Brin and sister of YouTube CEO Susan Wojcicki.)

Ancestry DNA

• Price: $99 (plus $9.95 shipping)
• Tests: Autosomal
• Match Database: 5 million
• Autosomal SNPs tested: 650,000

Ancestry is the big name in DNA testing, in part because of its ongoing affiliation with the Mormon Church and its fascination with genealogical record keeping. Ancestry.com offers access to a wide range of databases and research resources.

The test kit gathers saliva from spit. It offers a free family tree tool to which users can contribute their specific results. You can also download your full DNA profile and import that data into another tool — but it doesn’t offer a chromosome browser, so you can’t really do DNA segment comparisons. Given this, if you’re a true DNA geek, Ancestry DNA may not be the service for you.

We liked that Ancestry stores your results forever, has a strong genealogical community and excellent family matching features. DNA reports don’t provide tremendous detail, but DNA results are segmented into 150 geographic regions, the most detailed geographic granularity of any of the services we’ve profiled.

Family Tree DNA

• Price: $79 (plus $12.95 shipping)
• Tests: Autosomal (other tests, such as mitochondrial DNA testing, sold separately)
• Match Database: 850,000
• Autosomal SNPs tested: 700,000

Family Tree DNA (FTDNA) is operated by Houston-based genetic testing lab Gene-by-Gene. Gene-by-Gene also operates the Genomics Research Center for National Geographics’ Genographic Project, which is also profiled in this roundup.

FTDNA offers a wide range of tests. The basic autosomal test costs $79 (plus shipping) and is conducted with a cheek swab. You can add sequences and markers, and your father’s line and mother’s line tests, but that will step up the price considerably. 

If you are interested in doing in-depth analysis, the FTDNA offers a chromosome browser, allows raw data to be uploaded, provides support for setting different segment matching thresholds, and allows up to five comparisons to be done at once. FTDNA allows trial transfers from 23andMe and Ancestry DNA into its match database; additional transfers of various datasets is available for a fee. FTDNA promises to keep data for 25 years.

MyHeritage

• Price: $79 
• Tests: Autosomal (other tests sold separately)
• Match Database: 102 million
• Autosomal SNPs tested: 710,000

Offering DNA test kits and a range of online subscription services, MyHeritage says that its database includes more ethnicities — that’s 42 — than any other major testing service. The free 14-day trial will let you poke around the company’s massive online database which includes 3.5 billion profiles in addition to information about over 100 million subscribers and their collective 46 million family trees. 

Starting at $79, the company’s DNA test kit is competitively priced and covers the basics: A simple cheek swab will give you an analysis of your ethnic origins and the identification of relatives who share your DNA. In addition to MyHeritage’s free basic subscription, which will let you assemble a family tree up to 250 people, there are other packages that accommodate larger trees, advanced DNA features, and more robust research tools. The company allows you to upload test data from other companies.

MyHeritage says that it has also sold more than one million DNA testing kits — but its enormous database is largely powered by Geni.com, a genealogy social media site, that has assembled “the world’s largest, scientifically vetted family tree,” according to the New York Times. (MyHeritage is Geni.com’s parent company.) 

HomeDNA

• Price: $59 (more in-depth tests additional)
• Tests: Autosomal, Y-DNA
• Match Database: None
• Autosomal SNPs tested: 850,000

HomeDNA is kind of like the Walmart of DNA testing, which is somewhat appropriate given that the company’s tests are sold at Walmart stores in addition to CVS, Rite Aid, and Walgreens pharmacies.

HomeDNA offers a range of ancestry services priced between $69 to $199. Though the jury is still out about the effectiveness of specialty tests, HomeDNA also sells test kits to determine food and pet sensitivity ($99), diet and exercise strategies based on your genetic makeup ($119), paternity ($164), and even skin care ($99).

Dog owners can buy a dog DNA test to help you determine your dog’s breed history for $125. You can also buy a $125 health screening for your dog or cat that includes a series of tests for genetic diseases and traits.

Testing is done with a mouth swab. Shipping is free. And results are kept for 25 years.

National Geographic Geno DNA Kit

• Note: This service is no longer available
• Tests: Autosomal, Y-DNA, mtDNA
• Match Database: 230,000
• Autosomal SNPs tested: 700,000

National Geographic ended the public participation phase of its genographic research project on May 31, 2019. Its Geno 2.0 DNA Ancestry kits are no longer available for purchase. According to the company’s website: “If you have already purchased a kit, you may still send it in for processing in accordance with the Terms and Conditions of sale.”

National Geographic plans to maintain the database where customers can access their results online, until the end of 2020. You can learn more about the project on National Geographic’s website.

African Ancestry

African Ancestry can’t compete on price or the size of its match database, but it does offer deep regional analysis. It’s a worthy specialized service for individuals looking at exploring African ancestry.

Rather than a match database of individuals, African Ancestry has the world’s largest database of African lineages. The company can trace your ancestry back to a region in Africa and then pinpoint its location today. It can also dive deep into history and help find original ethnic groups that may date back as long as 500 years ago.

But the tests can get quite expensive. The company sells a maternal test kit and a paternal test kit for $299 each (shipping is free). If you want to trace your family back both through male and female ancestors, it’ll cost you about $600. Still, for African family histories, the depth of analysis is unique among the services we profiled.

Full Genomes

• Price: $645 (more in-depth tests additional)
• Tests: Autosomal, Y-DNA, mtDNA
• Match Database: None
• Autosomal SNPs tested: 71,000

The Full Genomes service is so expensive, it offers a payment plan. But the service offers the largest library of Y-chromosome SNPs around. So if you want to explore your patrilineal background, this is the most comprehensive option on the market. There’s no family match database, however. 

Testing is done with a cheek swab. The company charges $25 for shipping.

Living DNA

• Price: $79
• Tests: Autosomal, Y-DNA, mtDNA
• Match Database: Just getting started
• Autosomal SNPs tested: 638,000

Living DNA is a UK-based genomics firm that offers autosomal DNA data, as well as a breakdown of matrilineal and patrilineal lines. DNA data is gathered through a mouth swab. 

Living DNA has a very limited family match database, so if you’re looking for a service that can match you to relatives around the world, this is not the one for you. But Living DNA’s test is quite comprehensive: it tests 638,000 autosomal SNPs, 22,500 Y chromosome SNPs and 17,800 X chromosome SNPs, along with 4,700 mitochondrial SNPs.

And the service tracks DNA to 80 geographic regions. Those with a UK family history will see a map of where ancestors lived on the islands. Though we didn’t test it first hand, Living DNA says its tools allow you to upload DNA data from other services to predict relationship matches.

DNA testing: What you need to know

If you’re using a home DNA testing service, you’re likely looking for one of three things:

Ancestry and family history: The first big draw of a full DNA test is that you’ll get a detailed breakdown on ancestry and ethnicity, and the migration patterns of your common ancestors. Spoiler alert: Your ethnic background may be radically different than you think it is.

Relative identification: With your permission, some DNA services will let you connect with relatives you never knew you had — other folks with matching DNA who have used the service and likewise given their permission to connect to possible relations.  

Health and disease info: DNA testing can also indicate which conditions for which you may have a preponderance. It’s a controversial feature, to be sure. Knowing that you have a genetic predisposition to a certain form of cancer may make you more vigilant for testing, but it may also lead to increased stress — worrying about a potential condition that may never develop, even if you’re “genetically susceptible” to it. The possibility of false positives and false negatives abound — any such information should be discussed with your doctor before you act upon it.

How DNA tests work

Afraid of needles and drawing blood? Good news: That’s not an issue with these tests. All you need to do is spit into a vial or rub a swab in your mouth — all the genetic data needed for these tests is present in your saliva — and ship the DNA sample to the company for analysis. 

The reason that a saliva sample works as well as blood (or hair follicles or skin samples) is that your DNA — which is short for deoxyribonucleic acid — is present in all of them. It’s the basic genetic code present in all of your cells that makes up your key attributes, from the color of your eyes to the shape of your ears to how susceptible you are to cholesterol.

The key terms you need to know when comparing DNA testing services are:

SNP (single nucleotide polymorphism): Genotyping is done by measuring genetic variation. One of the more common is SNP genotyping, which measures the variations of a single nucleotide polymorphism. In our service summaries below, we discuss the number of SNPs. That’s because the more a company measures, the more granular the variations analyzed.

Autosomal DNA testing: An autosomal test can be administered to both men and women, and traces lineage back through both the maternal and paternal bloodlines.

Y-DNA: The Y-DNA test can only be administered to men, and traces DNA back through the patrilineal ancestry (basically from father to grandfather to great grandfather).

mtDNA: The mtDNA is matrilineal and lets you trace your ancestry back through your mother, grandmother and great grandmother. 

Autosomal tests can get you quality genetic information going back about four or five generations. Because the Y-DNA and mtDNA tests are more focused on one side of the line, you can get information going back farther, but with less data about family structure. 

Four important caveats

Before you use any of the services we’ve highlighted below, keep these important factors in mind.

Match database size: If you’re looking for family relations, this is important. Simply put, the bigger the pool of available data, the better the chance you’ll have of finding a match.

Privacy concerns: Nothing is more private than your health data, which is why you should make sure a prospective DNA testing site follows the same best-practice online security protocols you’d expect from your bank or email provider. You’ll want to look for two-factor authentication, an encrypted password database and so on.