The order of play for Friday had Murray and Williams’ match against Andreas Mies and Alexa Guarachi down as ‘To be arranged’ throughout the day.
But by 6pm, the match was moved to Centre Court with the high-profile pairing getting prime-time billing after Cori Gauff’s clash with Polona Hercog.
However, after Gauff won the second set tiebreak to force a third set, officials promptly decided to postpone Murray and Williams’ match for the night.
The decision means Murray and Williams face the prospect of playing twice on Saturday to make up time.
Williams is currently scheduled first on Court 1 against Julia Goerges in the women’s singles at 1pm while Murray is in second-round men’s doubles action with Pierre-Hugues Herbert on Court 2 at the same time.
The schedule for Saturday has Murray and Williams’ mixed match rearranged for ‘Not before 5.30pm’.
And that means should Murray and Williams win their match, the second round clash will be played Monday because there is no play at Wimbledon on Sunday.
And if Murray and Williams have won both their matches on Saturday, they are likely to play two games again on Monday, compromising their schedule in the second week.
If Williams beat Goerges, her quarter-final match is due to be played on Tuesday. Meanwhile, Murray could still be in men’s doubles action, which is best of five.
Ahead of the match, Murray told the BBC that the pairing had allowed him to get to know Williams, a fellow parent, better.
“Playing mixed doubles with Serena is something that hadn’t been on my mind until this opportunity came up,” he said.
“I don’t know her that well and we haven’t played together before or spent much time hanging out – so let’s see what happens!
“But I think we do a lot of things quite similarly on court that should bode well for us as a partnership.
“Both of us play predominantly from the baseline and we are both good movers and athletes. And she serves unbelievably well.
“I don’t think we have ever hit together over the years, but hopefully we are going to do that today before this evening’s match.
“Serena’s coach Patrick Mouratoglou has been keen for us to have at least one practice together before we go out so we can have a chat about things together on court.
“We did chat briefly here at Wimbledon the other day and we spoke a little bit about the tennis – what side of the court we are going to play on. We also spoke about our injuries because she has had some issues with her knee recently and I’ve had the problems with my hip.
“Aside from that, we were chatting about parenting because we’ve both got kids that are similar ages and that led to discussing how handy the crèche is here on site, which a lot of the players use.
“But the conversation hasn’t extended to exchanging any parenting tips just yet.”