The NFL Competition Committee unanimously passed the rule on Thursday that will remain in place for 2019 and will be evaluated after the season.
The changes to the rules will allow coaches to challenge pass interference calls or no-calls up until the two-minute warning of either half.
During the two-minute window and during overtime, on-site replay officials will be responsible for stopping the game to review pass interference, as they are for all other reviewable plays.
This announcement will be bittersweet for the New Orleans Saints and their fans, as it was a missed pass interference call during their Championship game against the Los Angeles Rams which caused outrage across the NFL and sparked the debate about replays being used for pass interference calls.
It incident in question began when the Saints had possession of the ball with 1:49 left on the clock in the fourth quarter.
Saints quarterback Drew Brees dropped back and threw a pass in the direction of Tommylee Lewis on the sideline.
As Lewis made a move to catch the ball near the 5-yard-line, Rams corner Nickell Robey-Coleman smashed into the Saints receiver before to the ball got to him.
No flags were thrown by the officials and the home crowd and the Saints bench showed their disapproval.
As the rules stood at the time because no call was made, the incident was not reviewable via instant replay, however, that has now changed for next season.
The committee said in a statement: “The replay official will stop the game after the two-minute warning of each half and during OT.
“When there is ‘clear and obvious visual evidence’ that a pass interference foul may or may not have occurred, based on viewing the play live or any initial replays, a stoppage will occur under stricter criteria than for other reviewable plays to prevent excessive game stoppages.
“A decision on the field will only be reversed based on ‘clear and obvious visual evidence’ that the ruling was incorrect, the same standard for all reviews.
“This is wholly dependent on video angles shown by broadcast networks.
“By rule, pass interference requires an act that ‘significantly hinders’ an opponent’s opportunity to make a play on the ball.
“All passing plays will be subject to review for pass interference.
“The ‘Hail Mary’ play will be reviewed in replay consistent with the guidelines for officiating the play on the field.”