The Reds suffered a damaging 3-0 defeat at the Nou Camp on Wednesday that leaves them with a mountain to climb in their Champions League semi-final.
Former Liverpool striker Luis Suarez opened the scoring before a Lionel Messi double took the game away from Jurgen Klopp’s men in seven second-half minutes.
To add insult to injury, Naby Keita was forced off with what appeared to be groin problem in the early stages of the match and is unlikely to face Newcastle.
The Guinea international joins Adam Lallana on the treatment table, although the Liverpool squad otherwise has a clean bill of health.
Roberto Firmino was fit enough for the bench against Barcelona after a muscle strain in training and was called upon after the break as the Reds pushed for a precious away goal.
The Brazilian is expected to start up front against Newcastle with Mohamed Salah and Sadio Mane reverting to their usual positions on the flank.
Fabinho, Jordan Henderson and Georginio Wijnaldum are likely to make up the midfield three if James Milner is rested.
In defence, Trent Alexander-Arnold is set for a return after being overlooked in favour if Joe Gomez at the Nou Camp.
The rest of the back four will remain unchanged with Joel Matip partnering Virgil van Dijk in central defence and Andrew Robertson at left-back.
Alisson will continue in goal with Xherdan Shaqiri, Daniel Sturridge and Divock Origi attacking options off the bench.
Liverpool are currently a single point behind Manchester City in the race for the Premier League with just two matches remaining.
The Reds welcome Wolves to Anfield on the final day of the season while City host Leicester on Monday night before travelling to Brighton next Sunday.
Liverpool predicted line-up vs Newcastle United – Premier League
(4-3-3): Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Fabinho, Henderson, Wijnaldum; Salah, Mane, Firmino