Khan is loooking to fulfill his dream of becoming a two-weight world champion when he meets Crawford in the middle of the ring later tonight.
But Khan and Crawford aren’t the only fighters taking to the stage in front of thousands of people at the Garden.
Three other bouts are scheduled to take place before the main event.
Rising star Teofimo Lopez, Shakur Stevenson and Christopher Diaz will all be looking to dazzle spectators at the mecca of boxing.
The undercard gets underway around 2am live on BT Sport Box Office, with the main event set to kick off around 4am.
Lopez, who comes up against Finnish fighter Teofimo Lopez, is looking to cement a fight with pound-for-pound king Vasyl Lomachenko later this year.
Stevenson, who comes up against Freddie Roach-trained Christopher Diaz, is hoping a win can push him one step further to a title fight with Josh Warrington.
Elsewhere on the undercard, Felix Verdejo takes on Bryan Vasquez in a lightweight bout.
Amir Khan vs Terence Crawford FULL CARD
Terence Crawford (champion) vs. Amir Khan (challenger), 12 rounds, Crawford’s WBO welterweight world title
Teofimo Lopez vs. Edis Tatli, 12 rounds, Lopez’s NABF lightweight title
Shakur Stevenson vs. Christopher Diaz, 10 rounds, Stevenson’s IBF Intercontinental, and vacant NABO featherweight titles
Felix Verdejo vs. Bryan Vasquez, 10 rounds, lightweight
Preliminary undercard
Carlos Adames vs. Frank Galarza,10 rounds, Adames’ NABF, and vacant NABO 154-pound titles
Edgar Berlanga vs. Samir Barbosa, 8 rounds, middleweight
Larry Fryers vs. Dakota Polley, 6/4 rounds, super lightweight
Vikas Krishan vs. Noah Kidd, 6 rounds, super welterweight
Lawrence Newton vs. Jonathan Garza, 6 rounds, bantamweight